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My twin brother and I, are the youngest of 6 brothers, we are 65 years old.

Five years ago I was diagnosed with Parkinson’s disease. Despite all the medication, the deterioration has been constant and steady. 

I am told that the development of the disease is typical, with tremors, uncontrollable shaking, and regular lockup of the legs in mid stride, making it impossible to move. I also experienced constant and sometimes severe pain, in the shoulders, arms, legs and feet.

Deterioration was at the stage, where it was impossible for me to get out of bed, without the assistance of one or more of my brothers. This caused a tremendous strain on their health, as they had to get out of bed four or five times every night, to assist me to the bathroom.

One of the side effects of the medication I am taking is fluid retention.

For that, I was prescribed a diuretic. In order to preserve their own health, my brothers (we are all bachelors, co-habiting), was discussing the possibility of placing me in a high age-care facility. It scared me, to leave the home, where we have all lived together all our lives.

I was recommended to start to regularly take Laminine, along with my long list of Dr’s medication.

Due to the many side effects I am experiencing with the drugs, I was sceptical to say the least, but I was assured that Laminine was a food rather than a medication.

So I tried it and this is what has happened so far. Three days after taking 2 Laminine capsules two times per day (morning and afternoon), I was able to get out of bed on my own. This was in the morning and also during the night, giving my brothers their well-earned rest.

 

After taking Laminine for seven days, it was recommended that I stop taking the diuretic for at least one day, to see if there is fluid retention. There was none.

The result is that I could now sleep for at least six hours between bathroom calls. I have not taken any diuretics since then.

After ten days, I decided to walk over, to visit a relative, living 2 miles away. It was an energetic walk. With the energy that I felt, I almost wanted to run the distance, as we used to do in our younger days. I have now done it twice.

The first time, they drove me back home. On Sunday, I also walked back on my own. I have been taking Laminine now for three weeks, and I noticed that the pain in my legs and feet is not as severe. I am also back, doing what I like best, preparing the evening meal for my brothers. I am seeing the specialist in the first week of August, and I hope, seeing my changes, he will want to take me off the other medications too.

Parkinson's disease affects the way you move. It happens when there is a problem with certain nerve cells in the brain.

Normally, these nerve cells make an important chemical called dopamine. Dopamine sends signals to the part of your brain that controls movement. It lets your muscles move smoothly and do what you want them to do. When you have Parkinson's, these nerve cells break down. Then you no longer have enough dopamine, and you have trouble moving the way you want to.

Parkinson's is progressive, which means it gets worse over time. But usually this happens slowly, over many years. And there are good treatments that can help you live a full life.

No one knows for sure what makes these nerve cells break down. But scientists are doing a lot of research to look for the answer. They are studying many possible causes, including aging and poisons in the environment.

Abnormal genes seem to lead to Parkinson's disease in some people. But so far, there is not enough proof to show that it is always inherited.

The four main symptoms of Parkinson's are:

  • Tremor, which means shaking or trembling. Tremor may affect your hands, arms, or legs.
  • Stiff muscles.
  • Slow movement.
  • Problems with balance or walking.

Tremor may be the first symptom you notice. It's one of the most common signs of the disease, although not everyone has it.

Brain cells in Parkinson's disease exhaust themselves and die prematurely, burning out like an "overheating motor", an early study suggests.

Canadian researchers say the findings might help explain why only small parts of the brain are affected in the disease.

Parkinson's is caused by a loss of nerve cells in certain areas of the brain - but why these cells are vulnerable has been a mystery.

The work appears in Current Biology.

Tremor and stiffness

An estimated 127,000 people in the UK have Parkinson's disease, which can lead to a pronounced tremor, slow movement, and stiff and inflexible muscles.

In this paper, scientists from the University of Montreal studied the disease in mice cells.

They found, unlike other similar brain cells, neurons most often involved in Parkinson's disease were complex and had many more branches.

The cells also had much higher energy requirements, producing more waste products as they met this need.

Researchers suggest it is the accumulation of these waste products that triggers cell death.

Prof Louis-Eric Trudeau said: "Like a motor constantly running at high speed, these neurons need to produce an incredible amount of energy to function.

"They appear to exhaust themselves and die prematurely."

The team hope this finding may help create better experimental models of Parkinson's and identify new treatments.

'Rekindle interest'

They suggest, for example, that medication could one day be developed to help reduce the energy requirement of cells or increase their energy efficiency.

Dr Arthur Roach, at the charity Parkinson's UK, said:"Out of the billions of cells in the brain, it is always the same small group that degenerate and die in Parkinson's. We don't know why only these cells are affected.

"This study provides strong support to the idea that it is the unique structure and function of these cells that makes them especially susceptible to a damaging process called oxidative stress.

"We hope that this study will rekindle interest in the approach, and even lead to new treatments based on the most up-to-date ideas about oxidative stress."

http://www.bbc.com/news/health-34074526

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